Urinary levoglucosan as a biomarker of wood smoke: Results of human exposure studies

Megan A. Bergauff, Tony J. Ward, Curtis W. Noonan, Christopher T. Migliaccio, Christopher D. Simpson, Ashley R. Evanoski, Christopher P. Palmer

Research output: Contribution to journalArticlepeer-review

Abstract

Urinary levoglucosan was investigated as a potential biomarker of wood smoke exposure in two different controlled experimental settings. Nine subjects were exposed to smoke from a campfire in a controlled setting, and four were exposed to smoke from an older-model wood stove. All subjects were asked to provide urine samples before and after exposure, and to wear personal particulate matter with a diameter of ≤2.5 μm (PM2.5) monitors during exposure. Urinary levoglucosan measurements from both studies showed no consistent response to the smoke exposure. A third experiment was conducted to assess the contribution of dietary factors to urinary levoglucosan levels. Nine subjects were asked to consume caramel and provide urine samples before and after consumption. Urinary levoglucosan levels increased within 2 h of caramel consumption and returned to pre-exposure levels within 24 h. These studies suggest that diet is a major factor in determining urinary levoglucosan levels and that recent dietary history needs to be taken into account for future work involving levoglucosan as a biomarker of wood smoke exposure.

Original languageEnglish
Pages (from-to)385-392
Number of pages8
JournalJournal of Exposure Science and Environmental Epidemiology
Volume20
Issue number4
DOIs
StatePublished - Jun 2010

Keywords

  • Exposure assessment
  • Levoglucosan
  • Particulate matter
  • Urine
  • Wood smoke

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