Urinary levoglucosan as a biomarker of wood smoke: Results of human exposure studies

Megan A. Bergauff; Tony J. Ward; Curtis W. Noonan; Christopher T. Migliaccio; Christopher D. Simpson; Ashley R. Evanoski; Christopher P. Palmer

doi:10.1038/jes.2009.46

Urinary levoglucosan as a biomarker of wood smoke: Results of human exposure studies

Megan A. Bergauff
, Tony J. Ward
, Curtis W. Noonan
, Christopher T. Migliaccio
, Christopher D. Simpson
, Ashley R. Evanoski
, Christopher P. Palmer

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Urinary levoglucosan was investigated as a potential biomarker of wood smoke exposure in two different controlled experimental settings. Nine subjects were exposed to smoke from a campfire in a controlled setting, and four were exposed to smoke from an older-model wood stove. All subjects were asked to provide urine samples before and after exposure, and to wear personal particulate matter with a diameter of ≤2.5 μm (PM_2.5) monitors during exposure. Urinary levoglucosan measurements from both studies showed no consistent response to the smoke exposure. A third experiment was conducted to assess the contribution of dietary factors to urinary levoglucosan levels. Nine subjects were asked to consume caramel and provide urine samples before and after consumption. Urinary levoglucosan levels increased within 2 h of caramel consumption and returned to pre-exposure levels within 24 h. These studies suggest that diet is a major factor in determining urinary levoglucosan levels and that recent dietary history needs to be taken into account for future work involving levoglucosan as a biomarker of wood smoke exposure.

Original language	English
Pages (from-to)	385-392
Number of pages	8
Journal	Journal of Exposure Science and Environmental Epidemiology
Volume	20
Issue number	4
DOIs	https://doi.org/10.1038/jes.2009.46
State	Published - Jun 2010

Funding

This research was supported by the Health Effects Institute no. 4743-RFA04-4/06-4), NCRR (COBRE P20RR017670), the National Science Foundation Research Experience for Undergraduates (REU) program (no. 0649306), the National Institute of Environmental Health Sciences (1R01ES016336-01), and the National Institute of Occupational Safety and Health (R03-OH007656).

Funders	Funder number
0649306
R01ES016336
P20RR017670
National Institute for Occupational Safety and Health	R03-OH007656
4743-RFA04-4/06-4

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Exposure assessment
Levoglucosan
Particulate matter
Urine
Wood smoke

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10.1038/jes.2009.46

Cite this

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title = "Urinary levoglucosan as a biomarker of wood smoke: Results of human exposure studies",

abstract = "Urinary levoglucosan was investigated as a potential biomarker of wood smoke exposure in two different controlled experimental settings. Nine subjects were exposed to smoke from a campfire in a controlled setting, and four were exposed to smoke from an older-model wood stove. All subjects were asked to provide urine samples before and after exposure, and to wear personal particulate matter with a diameter of ≤2.5 μm (PM2.5) monitors during exposure. Urinary levoglucosan measurements from both studies showed no consistent response to the smoke exposure. A third experiment was conducted to assess the contribution of dietary factors to urinary levoglucosan levels. Nine subjects were asked to consume caramel and provide urine samples before and after consumption. Urinary levoglucosan levels increased within 2 h of caramel consumption and returned to pre-exposure levels within 24 h. These studies suggest that diet is a major factor in determining urinary levoglucosan levels and that recent dietary history needs to be taken into account for future work involving levoglucosan as a biomarker of wood smoke exposure.",

keywords = "Exposure assessment, Levoglucosan, Particulate matter, Urine, Wood smoke",

author = "Bergauff, \{Megan A.\} and Ward, \{Tony J.\} and Noonan, \{Curtis W.\} and Migliaccio, \{Christopher T.\} and Simpson, \{Christopher D.\} and Evanoski, \{Ashley R.\} and Palmer, \{Christopher P.\}",

note = "Funding Information: This research was supported by the Health Effects Institute no. 4743-RFA04-4/06-4), NCRR (COBRE P20RR017670), the National Science Foundation Research Experience for Undergraduates (REU) program (no. 0649306), the National Institute of Environmental Health Sciences (1R01ES016336-01), and the National Institute of Occupational Safety and Health (R03-OH007656).",

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AU - Simpson, Christopher D.

AU - Evanoski, Ashley R.

AU - Palmer, Christopher P.

N1 - Funding Information: This research was supported by the Health Effects Institute no. 4743-RFA04-4/06-4), NCRR (COBRE P20RR017670), the National Science Foundation Research Experience for Undergraduates (REU) program (no. 0649306), the National Institute of Environmental Health Sciences (1R01ES016336-01), and the National Institute of Occupational Safety and Health (R03-OH007656).

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N2 - Urinary levoglucosan was investigated as a potential biomarker of wood smoke exposure in two different controlled experimental settings. Nine subjects were exposed to smoke from a campfire in a controlled setting, and four were exposed to smoke from an older-model wood stove. All subjects were asked to provide urine samples before and after exposure, and to wear personal particulate matter with a diameter of ≤2.5 μm (PM2.5) monitors during exposure. Urinary levoglucosan measurements from both studies showed no consistent response to the smoke exposure. A third experiment was conducted to assess the contribution of dietary factors to urinary levoglucosan levels. Nine subjects were asked to consume caramel and provide urine samples before and after consumption. Urinary levoglucosan levels increased within 2 h of caramel consumption and returned to pre-exposure levels within 24 h. These studies suggest that diet is a major factor in determining urinary levoglucosan levels and that recent dietary history needs to be taken into account for future work involving levoglucosan as a biomarker of wood smoke exposure.

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Urinary levoglucosan as a biomarker of wood smoke: Results of human exposure studies

Abstract

Funding

UN SDGs

Keywords

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