This study measured self-reported quality of life at two time points for 50 diagnostically heterogeneous patients in a state-funded psychiatric hospital and evaluated the Quality of Life Inventory for assessing changes over inpatient treatment. Participants completed the Quality of Life Inventory after admission and before discharge. Improvement occurred in overall scores during participants' hospital stays. Analysis of domains showed improvements in satisfaction with health and self-esteem. The inventory appears a useful tool for evaluating outcomes of psychiatric inpatient treatment from a patient perspective.